Rain into a bacterial artificial chromosome and reconstitution of infectious virus. Vaccine 2007, 25(27):5006?012. 38. Zhang Z, et al: Genetic evaluation of varicella-zoster virus ORF0 to ORF4 by use of a novel luciferase bacterial artificial chromosome program. J Virol 2007, 81(17):9024?033. 39. Cohen JI: The varicella-zoster virus genome. Curr Top rated Microbiol Immunol 2010, 342:1?4. 40. Zhang Z, et al: Genome-wide mutagenesis reveals that ORF7 can be a novel VZV skin-tropic factor. PLoS Pathog 2010, 6:e1000971. 41. Chaudhuri V, et al: Functions of Varicella-zoster virus ORF23 capsid protein in viral replication along with the pathogenesis of skin infection. J Virol 2008, 82(20):10231?0246. 42. Selariu A, et al: ORF7 of varicella-zoster virus is a neurotropic element. J Virol 2012, 86(16):8614?624. 43. Oliver SL, et al: Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are necessary for viral replication, as well as the furin cleavage motif contributes to pathogenesis in skin tissue in vivo. J Virol 2009, 83(15):7495?506. 44. Brazeau E, et al: Simian varicella virus open reading frame 63/70 expression is needed for efficient virus replication in culture. J Neurovirol 2011, 17(three):274?80. 45. Estep RD, et al: Building of an infectious rhesus rhadinovirus bacterial artificial chromosome for the analysis of Kaposi’s sarcomaassociated herpesvirus-related illness development. J Virol 2007, 81(6):2957?969. 46. Robinson BA, et al: Viral interferon regulatory elements lower the induction of form I and kind II interferon through rhesus macaque rhadinovirus infection. J Virol 2012, 86(four):2197?211. 47. Wong CW, et al: Tracking the evolution with the SARS coronavirus using high-throughput, high-density resequencing arrays. Genome Res 2004, 14(three):398?05. 48. Gray WL: Simian varicella virus: molecular virology. Curr Prime Microbiol Immunol 2010, 342:291?08. 49. McNabb DS, Courtney RJ: Characterization in the large tegument protein (ICP1/2) of herpes simplex virus kind 1.Formula of 3,3,3-Triethoxyprop-1-yne Virology 1992, 190(1):221?32. 50. Heine JW, et al: Proteins specified by herpes simplex virus. XII. The virion polypeptides of variety 1 strains. J Virol 1974, 14(3):640?51. 51. Batterson W, Furlong D, Roizman B: Molecular genetics of herpes simplex virus.3-Amino-4-methylpicolinic acid uses VIII.PMID:32695810 Additional characterization of a temperature-sensitive mutant defective in release of viral DNA and in other stages in the viral reproductive cycle. J Virol 1983, 45(1):397?07. 52. Knipe DM, Ruyechan WT, Roizman B: Molecular genetics of herpes simplex virus. III. Fine mapping of a genetic locus determining resistance to phosphonoacetate by two approaches of marker transfer. J Virol 1979, 29(2):698?04. 53. Desai PJ: A null mutation within the UL36 gene of herpes simplex virus variety 1 outcomes in accumulation of unenveloped DNA-filled capsids inside the cytoplasm of infected cells. J Virol 2000, 74(24):11608?1618. 54. Hendricks RL, et al: Endogenously created interferon alpha protects mice from herpes simplex virus variety 1 corneal disease. J Gen Virol 1991, 72(Pt 7):1601?610.Meyer et al. Virology Journal 2013, 10:278 http://virologyj/content/10/1/Page 12 of55. Mikloska Z, Cunningham AL: Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells immediately after axonal transmission. J Virol 2001, 75(23):11821?1826. 56. Sainz B Jr, Halford WP: Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus kind 1. J Virol 2002, 76(22):11541?1550.doi:ten.1186/1743-4.